Dopamine markers and general cognitive ability.

Ball, D; Hill, L; Eley, T C; Chorney, M J; Chorney, K; Thompson, L A; Detterman, D K; Benbow, C; Lubinski, D; Owen, M; McGuffin, P; Plomin, R

Ball, D; Hill, L; Eley, T C; Chorney, M J; Chorney, K; Thompson, L A; Detterman, D K; Benbow, C; Lubinski, D; Owen, M; McGuffin, P; Plomin, R.

Afiliación

Ball D; Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Denmark Hill, London, UK.

Neuroreport ; 9(2): 347-9, 1998 Jan 26.

Article en En | MEDLINE | ID: mdl-9507981

RESUMEN

Because general cognitive ability (g) is among the most heritable behavioural traits, it is a reasonable target for a search for quantitative trait loci (QTLs). We used a selected-extremes design to test candidate genes for allelic association with g. Polymorphisms in four genes in the dopamine system (DRD2, DRD3, DRD4, DAT1) were genotyped for 51 high g children with IQ scores > 130 and for 51 average g control children. No significant allelic or genotypic differences were found between the high g and average g groups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5.

Asunto(s)

Cognición/fisiología; Dopamina/genética; Dopamina/fisiología; Adolescente; Alelos; Biomarcadores; Niño; ADN/análisis; Femenino; Genotipo; Humanos; Pruebas de Inteligencia; Masculino; Polimorfismo Genético; Carácter Cuantitativo Heredable

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dopamina / Cognición Tipo de estudio: Etiology_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Neuroreport Asunto de la revista: NEUROLOGIA Año: 1998 Tipo del documento: Article Pais de publicación: Reino Unido

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