Acetazolamide-induced severe pancytopenia mimicking myelodysplasia relapse following allogeneic bone marrow transplantation.

Maclean, R; O'Callaghan, U; Lim, S H

Maclean, R; O'Callaghan, U; Lim, S H.

Afiliación

Maclean R; Department of Haematology, University of Wales College of Medicine, Cardiff, UK.

Bone Marrow Transplant ; 21(3): 309-11, 1998 Feb.

Article en En | MEDLINE | ID: mdl-9489658

RESUMEN

Pancytopenia with severe bone marrow dysplasia following allogeneic bone marrow transplantation for acute myeloid leukemia (M6) may pose a diagnostic problem. We report a case of M6 acute myeloid leukemia in which progressive macrocytosis, pancytopenia and severe bone marrow dysplasia induced by acetazolamide therapy developed after successful engraftment of a donor marrow. We discuss the diagnostic problems and the usefulness of conventional cytogenetics and interphase fluorescence in situ hybridisation in excluding recipient myelodysplasia relapse. We also suggest that acetazolamide should be used with caution, especially following bone marrow transplantation.

Asunto(s)

Acetazolamida/efectos adversos; Trasplante de Médula Ósea; Síndromes Mielodisplásicos/diagnóstico; Pancitopenia/inducido químicamente; Adolescente; Femenino; Humanos; Leucemia Eritroblástica Aguda/complicaciones; Leucemia Eritroblástica Aguda/terapia; Osteogénesis Imperfecta/complicaciones; Pancitopenia/diagnóstico; Trasplante Homólogo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pancitopenia / Síndromes Mielodisplásicos / Trasplante de Médula Ósea / Acetazolamida Tipo de estudio: Diagnostic_studies Límite: Adolescent / Female / Humans Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 1998 Tipo del documento: Article Pais de publicación: Reino Unido

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