Second-trimester maternal urinary gonadotrophin peptide screening for fetal Down syndrome in Asian women.
Prenat Diagn
; 17(12): 1101-6, 1997 Dec.
Article
en En
| MEDLINE
| ID: mdl-9467806
Maternal urinary gonadotrophin peptide (UGP) was recently found to be elevated in second-trimester Down syndrome pregnancies. There is controversy about its screening efficacy. Data in the Asian population are scanty. We measured the UGP levels in 29 Down syndrome pregnancies and 297 controls and expressed them as a ratio of the urine creatinine concentration. Median UGP MOM was elevated to 3.44 (95 per cent confidence interval 1.99-5.13) in cases, compared with controls. UGP values were widely scattered in cases and controls with extensive overlap such that only 35 per cent of Down syndrome cases were expected to be detected at a 5 per cent false-positive rate. The data of the present study and previous reports show that there is a wide variability of gestation-specific UGP median values. UGP alone does not appear to be an effective screening marker for fetal Down syndrome.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Diagnóstico Prenatal
/
Síndrome de Down
/
Gonadotropina Coriónica Humana de Subunidad beta
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Pueblo Asiatico
/
Enfermedades Fetales
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Prenat Diagn
Año:
1997
Tipo del documento:
Article
País de afiliación:
Hong Kong
Pais de publicación:
Reino Unido