Helicobacter pylori promotes development of pepsinogen-altered pyloric glands, a preneoplastic lesion of glandular stomach of BALB/c mice pretreated with N-methyl-N-nitrosourea.
Cancer Lett
; 123(1): 63-9, 1998 Jan 16.
Article
en En
| MEDLINE
| ID: mdl-9461019
H. pylori is thought to be a stomach carcinogen. Since no experimental model has hitherto been established to clarify the relationship between H. pylori and stomach carcinogenesis, the effects of infection with the bacteria on experimental carcinogenesis in the glandular stomach of mice were investigated. BALB/c mice were given salty diet or N-methyl-N-nitrosourea (MNU) and administered broth culture of H. pylori. The incidence of pepsinogen-altered pyloric glands, considered as precancerous lesions, was increased in the H. pylori inoculated group pre-treated with MNU. The findings provide the new experimental model demonstrating the relationship between stomach cancer and H. pylori.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pepsinógenos
/
Lesiones Precancerosas
/
Helicobacter pylori
/
Infecciones por Helicobacter
/
Mucosa Gástrica
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Cancer Lett
Año:
1998
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Irlanda