Randomised, double-blind, placebo-controlled study of pivagabine in neurasthenia.

Pizzolato, G; Cagnin, A; Mancia, D; Caffarra, P; Avanzi, S; Copelli, S; Ciappina, C; Lo Presti, F; Spilimbergo, P G; D'Antonio, E; Di Costanzo, E; Matrango, M; Pastres, P; Urbani, P P; Signorino, M; Simoncelli, M; Provinciali, L; Regnicolo, L; Albano, C; Roccatagliata, G; Rubino, V; Cultrera, S; Fracassi, M

Pizzolato, G; Cagnin, A; Mancia, D; Caffarra, P; Avanzi, S; Copelli, S; Ciappina, C; Lo Presti, F; Spilimbergo, P G; D'Antonio, E; Di Costanzo, E; Matrango, M; Pastres, P; Urbani, P P; Signorino, M; Simoncelli, M; Provinciali, L; Regnicolo, L; Albano, C; Roccatagliata, G; Rubino, V; Cultrera, S; Fracassi, M.

Afiliación

Pizzolato G; Clinica Neurologica dell'Università di Padova, Italy.

Arzneimittelforschung ; 47(11A): 1329-31, 1997 Nov.

Article en En | MEDLINE | ID: mdl-9450159

RESUMEN

One hundred and eighteen patients with neurasthenia, as defined by ICD 10 (International Classification of Diseases), participated in a randomised, double-blind, placebo-controlled trial of pivagabine (4-[(2,2-dimethyl-1-oxopropyl)amino]butanoic acid, CAS 69542-93-4, Tonerg). Pivagabine 1800 mg/d was administered orally for four weeks. At the end of the trial, active medication was significantly superior to placebo on the Clinical Global Impression (CGI) improvement of illness scale. In addition, pivagabine treatment reduced the physical and mental fatigability of patients, and increased their sense of well-being.

Asunto(s)

Neurastenia/tratamiento farmacológico; Psicotrópicos/uso terapéutico; Ácido gamma-Aminobutírico/análogos & derivados; Adolescente; Adulto; Anciano; Método Doble Ciego; Femenino; Humanos; Masculino; Persona de Mediana Edad; Neurastenia/psicología; Escalas de Valoración Psiquiátrica; Psicotrópicos/efectos adversos; Ácido gamma-Aminobutírico/efectos adversos; Ácido gamma-Aminobutírico/uso terapéutico

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psicotrópicos / Ácido gamma-Aminobutírico / Neurastenia Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arzneimittelforschung Año: 1997 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania

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