Cyclooxygenase products contribute to endothelin-induced pulmonary hypertension and altered lung mechanics in sheep.
Pulm Pharmacol Ther
; 10(2): 111-8, 1997.
Article
en En
| MEDLINE
| ID: mdl-9425643
Endothelins have potent biological effect in vivo which may, in part, be mediated by stimulation of cyclooxygenase metabolism of arachidonic acid. We administered endothelins (ETs) intravenously to chronically instrumented awake sheep with and without pretreatment with meclofenamate (n = 8). 30 micrograms doses of ET-1, ET-2, and ET-3 caused similar degrees of acute elevation of pulmonary artery pressure (PPA), reduction of the dynamic compliance of the lungs (Cdyn), and increases in lung lymph flow. Pretreatment with meclofenamate inhibited the rise in PPA and reduction in Cdyn, but had no effect on lung lymph flow. We conclude that the biological effects of the endothelins on PPA and Cdyn, but not lung fluid balance, are mediated in part by cyclooxygenase products of arachidonic acid metabolism.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácido Meclofenámico
/
Endotelinas
/
Inhibidores de la Ciclooxigenasa
/
Hipertensión Pulmonar
/
Pulmón
Límite:
Animals
Idioma:
En
Revista:
Pulm Pharmacol Ther
Asunto de la revista:
FARMACOLOGIA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido