Your browser doesn't support javascript.
loading
Role of angiotensin II and bradykinin on aortic collagen following converting enzyme inhibition in spontaneously hypertensive rats.
Benetos, A; Levy, B I; Lacolley, P; Taillard, F; Duriez, M; Safar, M E.
Afiliación
  • Benetos A; Unit 337, INSERM, Paris, France.
Arterioscler Thromb Vasc Biol ; 17(11): 3196-201, 1997 Nov.
Article en En | MEDLINE | ID: mdl-9409311
We previously showed that chronic angiotensin-converting enzyme (ACE) inhibition prevented the increase in aortic collagen in spontaneously hypertensive rats (SHRs) independently of blood pressure reduction. The aim of the present study was to determine whether the effects of ACE inhibition on aortic fibrosis were due to inhibition of angiotensin II formation, preservation of bradykinin, or a combination of both. Four week-old SHRs were treated for 4 months with the ACE inhibitor quinapril, quinapril with the bradykinin B2 receptor antagonist Hoe 140, or the angiotensin II AT1 receptor antagonist CI996. Control SHR and Wistar-Kyoto (WKY) rats received a placebo for the same period of time. At the end of the treatment, as compared to conscious SHR and WKY controls, quinapril completely prevented the development of hypertension, whereas quinapril-Hoe 140 and the AT1 receptor antagonist produced only a partial reduction of blood pressure. In relation with blood pressure changes, aortic hypertrophy was significantly prevented by quinapril but not by quinapril-Hoe 140 or CI996. In contrast, aortic collagen accumulation was completely prevented by all three treatments. The study provides evidence that in young live SHRs, the prevention of aortic collagen accumulation is independent of blood pressure changes and bradykinin preservation and involves exclusively angiotensin II inhibition through AT1 receptors.
Asunto(s)
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aorta Torácica / Tetrazoles / Angiotensina II / Bradiquinina / Inhibidores de la Enzima Convertidora de Angiotensina / Colágeno / Tetrahidroisoquinolinas / Hipertensión / Imidazoles / Isoquinolinas Idioma: En Revista: Arterioscler Thromb Vasc Biol Asunto de la revista: ANGIOLOGIA Año: 1997 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aorta Torácica / Tetrazoles / Angiotensina II / Bradiquinina / Inhibidores de la Enzima Convertidora de Angiotensina / Colágeno / Tetrahidroisoquinolinas / Hipertensión / Imidazoles / Isoquinolinas Idioma: En Revista: Arterioscler Thromb Vasc Biol Asunto de la revista: ANGIOLOGIA Año: 1997 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos