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Sustained versus transient cyclic AMP intracellular levels: effect on thyrotropin-dependent growth of thyroid cells.
Villone, G; De Amicis, F; Veneziani, B M; Salzano, S; Di Carlo, A; Tramontano, D.
Afiliación
  • Villone G; Dipartimento di Medicina Sperimentale e Clinica, Università di Reggio Calabria, Catanzaro, Italy.
Cell Growth Differ ; 8(11): 1181-8, 1997 Nov.
Article en En | MEDLINE | ID: mdl-9372241
Cyclic AMP (cAMP) is the second messenger that stimulates growth and differentiation of thyroid cells, which are dependent upon thyrotropin for the initiation of the cell cycle. Treatment of thyroid cells with phosphodiesterase inhibitors, such as 1-methyl-3-isobutylxanthine (IBMX), RO-20-1724, or aminophylline, induces persistent levels of cAMP and blocks cell proliferation. IBMX-treated cells are arrested at the G1-S border, but removal of the drug allows cell growth to resume. The inhibiting effect of IBMX is dose dependent, and the phase of the cell cycle is irrelevant. These data indicate that prolonged and steady accumulation of cAMP blocks the cell cycle in thyroid cells.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándula Tiroides / Tirotropina / Sistemas de Mensajero Secundario / AMP Cíclico Límite: Animals Idioma: En Revista: Cell Growth Differ Asunto de la revista: BIOLOGIA MOLECULAR Año: 1997 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándula Tiroides / Tirotropina / Sistemas de Mensajero Secundario / AMP Cíclico Límite: Animals Idioma: En Revista: Cell Growth Differ Asunto de la revista: BIOLOGIA MOLECULAR Año: 1997 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos