Immobilization stress increases mRNA levels of interleukin-1 receptor antagonist in various rat brain regions.

Suzuki, E; Shintani, F; Kanba, S; Asai, M; Nakaki, T

Suzuki, E; Shintani, F; Kanba, S; Asai, M; Nakaki, T.

Afiliación

Suzuki E; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.

Cell Mol Neurobiol ; 17(5): 557-62, 1997 Oct.

Article en En | MEDLINE | ID: mdl-9353596

RESUMEN

1. Interleukin-1 receptor antagonist (IL-1Ra), as well as the interleukin-1 beta (IL-1 beta) gene response to immobilization stress (IMS), was examined in the rat brain. The reverse transcription-polymerase chain reaction was employed to determine mRNA levels. 3. IL-1 beta and IL-1Ra mRNA levels peaked at approximately 0.5 and 2-4 hr, respectively. The maximum mRNA levels of IL-1 beta were 15-fold higher than pre-IMS levels, whereas those of IL-1Ra were 250-fold higher in the hypothalamus. 3. After the biosynthesis of IL-1 beta has peaked, IL-1Ra may contribute to attenuation of the IL-1 activity which has been enhanced by IMS.

Asunto(s)

Química Encefálica/fisiología; Encéfalo/fisiopatología; Sialoglicoproteínas/genética; Estrés Fisiológico/fisiopatología; Animales; Expresión Génica/fisiología; Proteína Antagonista del Receptor de Interleucina 1; Masculino; Reacción en Cadena de la Polimerasa; ARN Mensajero/metabolismo; Ratas; Ratas Sprague-Dawley; Receptores de Interleucina-1/antagonistas & inhibidores; Receptores de Interleucina-1/fisiología; Restricción Física; Transducción de Señal/fisiología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sialoglicoproteínas / Estrés Fisiológico / Encéfalo / Química Encefálica Límite: Animals Idioma: En Revista: Cell Mol Neurobiol Año: 1997 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos

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