The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves.
Vet Res Commun
; 21(7): 521-31, 1997 Oct.
Article
en En
| MEDLINE
| ID: mdl-9345719
The in vivo ability of the specific PAF-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit platelet-activating factor (PAF) in cattle was investigated by in vitro determination of platelet aggregation curves. WEB 2086 was infused intravenously into a group of 5 healthy male Friesian calves in a dose of 3 mg/kg over 1 min. The resultant inhibition peaked between 30 min and 1 h after administration of WEB 2086. The inhibition was significantly reduced after 3 h and became non-significant after 6 h, but maximal pre-treatment aggregation had not been restored by 24 h after the injection of WEB 2086. These results confirm previous results obtained in vitro and suggest that WEB 2086 is a potent antagonist of PAF activity in calves. They also suggest that further clinical studies with WEB 2086 in cattle are desirable.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Azepinas
/
Triazoles
/
Bovinos
/
Inhibidores de Agregación Plaquetaria
/
Factor de Activación Plaquetaria
/
Agregación Plaquetaria
Límite:
Animals
Idioma:
En
Revista:
Vet Res Commun
Año:
1997
Tipo del documento:
Article
País de afiliación:
Bélgica
Pais de publicación:
Suiza