Longitudinal evaluation of severely anemic children in Kenya: the effect of transfusion on mortality and hematologic recovery.
AIDS
; 11(12): 1487-94, 1997 Oct.
Article
en En
| MEDLINE
| ID: mdl-9342071
ABSTRACT
PIP: The effect of blood transfusion on hematologic recovery and mortality both during and after hospitalization was investigated in a survey of children admitted to Siaya District Hospital (Kenya) in a 6-month period in 1991 with hemoglobin under 5.0 g/dl (n = 303) or 5.0 g/dl and above (n = 303). Children with hemoglobin under 5.0 g/dl (severe anemia) were younger and more likely to have malaria parasitemia and respiratory compromise than controls. 88 severely anemic children (30%) died during the study period. Severely anemic children who were transfused had a higher mean hemoglobin level at discharge (9.0 g/dl) than nontransfused children (5.8 g/dl) and maintained a higher mean hemoglobin in the 8-week post-discharge follow-up period. 15% of transfused and 17% of nontransfused children died after hospital discharge. Transfusion was associated with significantly improved survival among children with respiratory distress who were transfused within 2 days of hospital admission. However, the presence of malaria or parasitemia at follow-up negated the benefit of transfusion on hematologic recovery. These findings suggest that the effectiveness of transfusion can be enhanced by targeting severely anemic children with cardiorespiratory compromise, improving immediate access to blood, and effective antimalarial therapy. In addition, more information is needed on the causes of death among anemic children and the prevention of severe anemia.
Palabras clave
Africa; Africa South Of The Sahara; Age Factors; Anemia--prevention and control; Blood Transfusion; Child; Child Mortality; Child Survival; Demographic Factors; Developing Countries; Diseases; Eastern Africa; English Speaking Africa; Kenya; Length Of Life; Malaria; Mortality; Parasitic Diseases; Population; Population Characteristics; Population Dynamics; Prospective Studies; Research Methodology; Research Report; Studies; Survivorship; Treatment; Youth
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Reacción a la Transfusión
/
Anemia
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Infant
/
Male
País/Región como asunto:
Africa
Idioma:
En
Revista:
AIDS
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido