The consequences of the intracellular retention of pathogen-derived T-cell-independent antigens on protein presentation to T cells.
Clin Immunol Immunopathol
; 85(1): 1-15, 1997 Oct.
Article
en En
| MEDLINE
| ID: mdl-9325063
Intracellular pathogens can be considered as particulate antigens chemically composed of a complex mixture of T-cell-dependent antigens (TD) (peptides and proteins) and T-cell-independent antigens (TI) (glycolipids and complex polysaccharides). A large range of saccharides (from oligosaccharides to complex polysaccharides) derived from pathogenic microorganisms are being isolated and characterized. They are currently implicated in signaling systems and concomitant host-parasite relationships. However, there are not many structure-function relationships described for these pathogens. This is particularly true of polysaccharides. In this report we have reviewed the role of defined TI antigens in the processing and presentation of defined TD antigens to specific T cells by antigen-presenting cells (APC). We also considered the importance of some of the chemical characteristics shared by different carbohydrates implicated in the inhibition of antigen presentation. These findings are discussed in relation to the clear immunopathological consequences of long retention periods of complex carbohydrate molecules derived from intracellular parasites inside certain APC and the absence of antigen presentation impairment in physiological situations such as the removal of senescent or damaged red blood cells by splenic macrophages or intracellular accumulation of carbohydrates in colostrum and milk macrophages during lactation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Proteínas
/
Presentación de Antígeno
/
Antígenos T-Independientes
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Clin Immunol Immunopathol
Año:
1997
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Estados Unidos