Synergistic anticryptosporidial potential of the combination alpha-1-antitrypsin and paromomycin.
Antimicrob Agents Chemother
; 41(9): 2006-8, 1997 Sep.
Article
en En
| MEDLINE
| ID: mdl-9303402
The combined effect of the serine protease inhibitor alpha-1-antitrypsin (AAT) and the aminoglycoside paromomycin on Cryptosporidium parvum infection in vitro was investigated. AAT and paromomycin were mixed with C. parvum oocysts as either single or combined treatments and used to inoculate epithelial cell cultures. Single- and combined-treatment groups had significantly lower (P < 0.01) parasite numbers than untreated controls. The mean fractional inhibitory concentration indices suggested significant synergistic activity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Paromomicina
/
Inhibidores de Serina Proteinasa
/
Alfa 1-Antitripsina
/
Cryptosporidium parvum
/
Coccidiostáticos
/
Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos