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The SH3 domain of Eps8 exists as a novel intertwined dimer.
Kishan, K V; Scita, G; Wong, W T; Di Fiore, P P; Newcomer, M E.
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  • Kishan KV; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA.
Nat Struct Biol ; 4(9): 739-43, 1997 Sep.
Article en En | MEDLINE | ID: mdl-9303002
SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Dominios Homologos src Límite: Animals Idioma: En Revista: Nat Struct Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 1997 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Dominios Homologos src Límite: Animals Idioma: En Revista: Nat Struct Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 1997 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos