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The Ras Guanine nucleotide Exchange Factor CDC25Mm is present at the synaptic junction.
Sturani, E; Abbondio, A; Branduardi, P; Ferrari, C; Zippel, R; Martegani, E; Vanoni, M; Denis-Donini, S.
Afiliación
  • Sturani E; Department of General Physiology and Biochemistry, Department of Biology, University of Milan, Via Celoria 26, Milano, 20133, Italia.
Exp Cell Res ; 235(1): 117-23, 1997 Aug 25.
Article en En | MEDLINE | ID: mdl-9281359
CDC25Mm, a mouse Ras-Guanine nucleotide Exchange Factor, is specifically expressed as a product of 140 kDa (p140) in the postnatal and adult brain. Immunohistochemical analysis indicates that it is present throughout the brain particularly concentrated in discrete punctate structures. Subcellular fractionation of the mouse brain shows that p140 is present in synaptosomes but not in highly purified synaptic vesicles. Moreover, isolated postsynaptic densities (PSDs) are largely enriched in CDC25Mm. This protein can be phosphorylated by calcium/calmodulin kinase II, the most abundant protein in PSDs. Altogether these results suggest that CDC25Mm is present at synaptic junctions and that it may be involved in synaptic signal transduction leading to Ras activation.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Encéfalo / Fosfoproteínas Fosfatasas / Proteínas de Ciclo Celular / Proteínas de Unión al GTP Límite: Animals Idioma: En Revista: Exp Cell Res Año: 1997 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Encéfalo / Fosfoproteínas Fosfatasas / Proteínas de Ciclo Celular / Proteínas de Unión al GTP Límite: Animals Idioma: En Revista: Exp Cell Res Año: 1997 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos