Interleukin-6 secretion in mice is associated with reduced glucose-6-phosphatase and liver glycogen levels.
Am J Physiol
; 273(2 Pt 1): E262-7, 1997 Aug.
Article
en En
| MEDLINE
| ID: mdl-9277378
Mice bearing interleukin-6 (IL-6)-secreting tumor were used to study the chronic effect of IL-6 on carbohydrate metabolism. Mice were injected with allogeneic tumor cells transduced with the murine IL-6 gene. Serum IL-6 levels were correlated exponentially with tumor weight. Secretion of IL-6 from the developed tumors was associated with decreased food consumption, reduced body weight, and reduced blood glucose levels. Insulin levels did not change, and 2-deoxyglucose uptake was not affected in most tissues examined. A significant increase of 2-deoxyglucose uptake was measured in the liver. Glycogen content in the liver determined 0, 6, 12, and 18 days after tumor inoculation was 42, 23, 12, and 3 mg/g, respectively. The activity of phosphoenolpyruvate carboxykinase was not affected. The activity of glucose-6-phosphatase (G-6-Phase) determined 6, 12, and 18 days after tumor injection was 84, 70, and 50% of G-6-Pase activity in pair-fed mice bearing nonsecreting tumors, respectively. G-6-Pase mRNA levels were markedly reduced due to inhibition of G-6-Pase gene transcriptional rate.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Interleucina-6
/
Glucosa-6-Fosfatasa
/
Glucógeno
/
Hígado
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Am J Physiol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Israel
Pais de publicación:
Estados Unidos