Therapeutic leukapheresis in hyperleucocytic leukaemias: lack of correlation between degree of cytoreduction and early mortality rate.

Porcu, P; Danielson, C F; Orazi, A; Heerema, N A; Gabig, T G; McCarthy, L J

Porcu, P; Danielson, C F; Orazi, A; Heerema, N A; Gabig, T G; McCarthy, L J.

Afiliación

Porcu P; Department of Medicine, Indiana University Medical Center, Indianapolis 46202-5283, U.S.A.

Br J Haematol ; 98(2): 433-6, 1997 Aug.

Article en En | MEDLINE | ID: mdl-9266944

RESUMEN

The clinical and laboratory data of 48 leukapheresis-treated patients with hyperleucocytic leukaemia (HL) was reviewed to assess the correlation between the degree of leucoreduction and early mortality. Leukapheresis resulted in > 50% leucoreductions and postapheresis WBC counts < 100 x 10(9)/l in most patients (64.5%). Patients presenting with neurological, respiratory or renal complications had higher early mortality rates than patients without such complications, despite similar initial WBC counts and comparable leucoreductions. Thus, in these patients, more efficient leucoreduction was not associated with improved early survival.

Asunto(s)

Leucaféresis/métodos; Leucemia Mielógena Crónica BCR-ABL Positiva/terapia; Leucemia Mieloide Aguda/terapia; Adolescente; Adulto; Anciano; Niño; Femenino; Humanos; Leucocitosis/etiología; Masculino; Persona de Mediana Edad; Tasa de Supervivencia; Resultado del Tratamiento

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Leucemia Mieloide Aguda / Leucaféresis Tipo de estudio: Etiology_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Haematol Año: 1997 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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