Moderate and advanced Alzheimer's patients exhibit platelet activation differences.

Davies, T A; Long, H J; Tibbles, H E; Sgro, K R; Wells, J M; Rathbun, W H; Seetoo, K F; McMenamin, M E; Smith, S J; Feldman, R G; Levesque, C A; Fine, R E; Simons, E R

Davies, T A; Long, H J; Tibbles, H E; Sgro, K R; Wells, J M; Rathbun, W H; Seetoo, K F; McMenamin, M E; Smith, S J; Feldman, R G; Levesque, C A; Fine, R E; Simons, E R.

Afiliación

Davies TA; Department of Biochemistry, Boston University School of Medicine, MA 02118, USA.

Neurobiol Aging ; 18(2): 155-62, 1997.

Article en En | MEDLINE | ID: mdl-9258892

RESUMEN

We previously reported that platelets from advanced sporadic Alzheimer's disease (AD) patients exhibit two defects: first, an aberrant signal transduction presenting as a thrombin-induced hyperacidification, which is more severe for donors with the apolipoprotein E4 allele (apoE4), and second, an AD-specific Amyloid Precursor Protein (APP) processing defect that presents as retention of APP on the activated platelets' surface and in independent of the apo E allele. This retention of membrane APP correlates with decreased release of soluble APP. To determine at what stage in the disease progression these defects appear, we performed signal transduction and secretion studies on moderate AD patients. Thrombin-activated platelets from these patients do not exhibit either hyperacidification or APP retention; their APP processing and secretion are normal by Western blotting, suggesting that the two platelet defects appear in the advanced stages of AD.

Asunto(s)

Enfermedad de Alzheimer/sangre; Activación Plaquetaria/fisiología; Adulto; Anciano; Anciano de 80 o más Años; Precursor de Proteína beta-Amiloide/sangre; Plaquetas/metabolismo; Western Blotting; Calcio/metabolismo; Degranulación de la Célula/fisiología; Citosol/metabolismo; Progresión de la Enfermedad; Citometría de Flujo; Humanos; Concentración de Iones de Hidrógeno; Indicadores y Reactivos; Potenciales de la Membrana/fisiología; Persona de Mediana Edad; Neutrófilos/metabolismo; Selectina-P/metabolismo; Trombina/metabolismo

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Activación Plaquetaria / Enfermedad de Alzheimer Límite: Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Neurobiol Aging Año: 1997 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links