Diagnostic value of inhibin immunoreactivity in ovarian gonadal stromal tumours and their histological mimics.
Histopathology
; 31(1): 67-74, 1997 Jul.
Article
en En
| MEDLINE
| ID: mdl-9253627
AIMS: Inhibin is a heterodimeric protein hormone which appears to be a sensitive serological and immunohistochemical marker of ovarian granulosa cell tumours. The purposes of this study were to examine inhibin immunoreactivity in a wide range of gonadal stromal neoplasms and to assess its value in the differential diagnosis of problematic ovarian tumours. METHODS AND RESULTS: Inhibin immunostaining was identified in eight cases of stromal hyperthecosis, 24 adult-type granulosa cell tumours, two juvenile granulosa cell tumours, nine Sertoli cell or Sertoli-Leydig cell tumours, one gynandroblastoma, three gonadoblastomas, two cases of sex cord tumour with annular tubules, two steroid cell tumours and two sclerosing stromal tumours. Inhibin was also present in 4/6 fibrothecomas and 2/3 unclassified gonadal stromal tumours. There was no staining of neoplastic cells in any of the problematic ovarian tumours, in many of which a diagnosis of gonadal stromal tumour had been initially considered. However, inhibin was detected in reactive stromal cells in many cases. CONCLUSIONS: Inhibin is a sensitive immunohistochemical marker of a wide range of gonadal stromal tumours and is of value in the differential diagnosis of ovarian neoplasia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades del Ovario
/
Neoplasias Ováricas
/
Tumores de los Cordones Sexuales y Estroma de las Gónadas
/
Inhibinas
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Histopathology
Año:
1997
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
Reino Unido