Effect of vitamin A supplementation on measles vaccination in nine-month-old infants.
Public Health
; 111(4): 245-7, 1997 Jul.
Article
en En
| MEDLINE
| ID: mdl-9242038
ABSTRACT
PIP: The feasibility of combining vitamin A supplementation and measles immunization was investigated in a double-masked, placebo-controlled clinical trial involving 394 9-months-old infants in Bogor district, West Java, Indonesia. Vitamin A, a potent immune enhancer, has been shown to reduce child mortality by 20-50% in developing countries and is among the most cost-effective child survival interventions. 130 infants received a placebo; 132 were given 25,000 IU of vitamin A at 6, 10, and 14 weeks and 100,000 IU at 9 months; and the final 132 were given 50,000 IU of vitamin A at 6, 10, and 14 weeks and 100,000 IU at 9 months. 37 (9.4%) of the study infants had pre-immunization measles titers greater than 1:120 at 9 months of age, indicative of a previous history of natural measles infection. 98.8% of the remaining infants had seroconverted to measles 1 month after immunization, regardless of whether they received vitamin A or placebo; after 6 months, 99.3% had titers consistent with protection against measles. Geometric mean titers were 1:1772 and 1:2298 at 1 month post-immunization and 1:1164 and 1:1900 at 6 months post-immunization in infants receiving vitamin A and placebo, respectively. Since vitamin A supplementation does not interfere with seroconversion to standard titer Schwarz measles immunization, its inclusion in Expanded Program on Immunization campaigns is recommended.
Palabras clave
Age Factors; Asia; Biology; Case Control Studies; Delivery Of Health Care; Demographic Factors; Developing Countries; Diseases; Health; Health Services; Immunization; Indonesia; Infant; Measles--prevention and control; Physiology; Population; Population Characteristics; Primary Health Care; Research Methodology; Research Report; Southeastern Asia; Studies; Vaccination; Viral Diseases; Vitamin A--beneficial effects; Vitamins; Youth
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vitamina A
/
Vacuna Antisarampión
/
Sarampión
/
Anticuerpos Antivirales
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
/
Infant
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Public Health
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Países Bajos