Disposition of single-dose intravenously administered enrofloxacin in emus (Dromaius novaehollandiae).
J Zoo Wildl Med
; 28(1): 43-8, 1997 Mar.
Article
en En
| MEDLINE
| ID: mdl-9226615
The pharmacokinetics of enrofloxacin in emus (Dromaius novaehollandiae) were examined following parenteral administration. A mean allometrically scaled dose of 2.2 +/- 0.03 mg/kg was administered as a single i.v. bolus, and serum samples were collected at predetermined intervals over a 24-hr period. Enrofloxacin levels were measured using high-performance liquid chromatography, and the resulting concentration versus time curve was analyzed using nonlinear regression with least squares parameter estimation. The data were best represented by a two-compartment model with a mean elimination half-life of 3.33 hr. Mean model independent parameters obtained were area under the curve (8.26 micrograms.hr/ml), mean residence time (4.40 hr), apparent volume of distribution (1.49 L/kg), and total body drug clearance (0.36 L/hr/kg). Mean serum concentrations exceeded the target peak of 2.0 micrograms/ml and remained above an estimated inhibitory concentration of 0.5 micrograms/ml for approximately 2 hr. Based upon the results of this study, enrofloxacin administered parenterally to emus at 2.2 mg/kg every 12 hr is expected to achieve therapeutic serum concentrations against susceptible organisms.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aves
/
Quinolonas
/
Fluoroquinolonas
/
Antiinfecciosos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Zoo Wildl Med
Asunto de la revista:
MEDICINA VETERINARIA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos