Stat1 in developing and adult rat brain. Induction after transient focal ischemia.
Neuroreport
; 8(6): 1359-62, 1997 Apr 14.
Article
en En
| MEDLINE
| ID: mdl-9172135
Stat1 has a dual function as signal transducer and activator of transcription, and is activated in response to growth factors and cytokines. We examined Stat1 in the rat brain during development and following transient focal ischemia, using Western immunoblotting. Two bands of 91 and 84 kDa, corresponding to Stat1 alpha and Stat1 beta forms, were found with an intensity that increased from postnatal day 0 to adulthood in cerebellum and cerebral cortex. Ischemia caused a strong induction of Stat1 in the ipsilateral cortex after 4, 7 and 15 days, but not at 6 or 24 h. These results show that Stat1 is normally expressed in the postnatal and adult rat brain and is induced under brain infarction.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Transducción de Señal
/
Transactivadores
/
Ataque Isquémico Transitorio
/
Proteínas de Unión al ADN
/
Proteínas del Tejido Nervioso
Límite:
Animals
Idioma:
En
Revista:
Neuroreport
Asunto de la revista:
NEUROLOGIA
Año:
1997
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Reino Unido