TGF-beta latency: biological significance and mechanisms of activation.

Gleizes, P E; Munger, J S; Nunes, I; Harpel, J G; Mazzieri, R; Noguera, I; Rifkin, D B

Gleizes, P E; Munger, J S; Nunes, I; Harpel, J G; Mazzieri, R; Noguera, I; Rifkin, D B.

Afiliación

Gleizes PE; Department of Cell Biology, New York University Medical Center, New York 10016, USA.

Stem Cells ; 15(3): 190-7, 1997.

Article en En | MEDLINE | ID: mdl-9170210

RESUMEN

Transforming growth factor (TGF-) beta is secreted as a latent complex in which the mature growth factor remains associated with its propeptide. In order to elicit a biological response, the cytokine must be released from the latent complex, a process termed latent TGF-beta activation or TGF-beta formation. Although latent TGF-beta activation is a critical step in the regulation of its activity, little is known about the molecular mechanisms that lead to the production of active TGF-beta. In this article, we present an overview of the data available on this topic, and we propose a tentative model for the mechanism of TGF-beta formation based upon the observations with different cell systems and on recent findings on the structure of the latent TGF-beta complex.

Asunto(s)

Células Madre/química; Células Madre/metabolismo; Factor de Crecimiento Transformador beta/química; Factor de Crecimiento Transformador beta/metabolismo; Animales

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Factor de Crecimiento Transformador beta Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Stem Cells Año: 1997 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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