Molecular genetic analysis of HLA-DRB, -DQA, and -DQB polymorphisms in Hungarians and distribution of the DRB1*03 allele in adults and newborns.
Exp Clin Immunogenet
; 13(3-4): 204-9, 1996.
Article
en En
| MEDLINE
| ID: mdl-9165274
We describe here the genetic variability of HLA-DRB1, -DQA, and -DQB in 140 healthy individuals from Hungary, including 95 randomly selected adults and 45 newborns. Allele and haplotype frequencies as well as linkage disequilibria were calculated. It was found that HLA-DRB1*11, -DQA1*0501, and -DQB1*0301 predominate in Hungarians. This information may be helpful in the future for HLA and disease association studies. Simultaneously, we observed that the frequency of the DRB1*03 allele differs between adults and newborns. Since it is well known that bearers of HLA-DR3 (and/or B8) antigens may display significant changes in immune parameters, the lower frequency in adults indicates that children with the DR3 antigen are predisposed to immune diseases in adulthood.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Antígenos HLA-DQ
/
Antígenos HLA-DR
Límite:
Adolescent
/
Adult
/
Humans
/
Middle aged
/
Newborn
País/Región como asunto:
Europa
Idioma:
En
Revista:
Exp Clin Immunogenet
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
GENETICA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Hungria
Pais de publicación:
Suiza