[Morpho-immunologic phenotypes of T-cell non-Hodgkin's malignant lymphoma in baboons and their connection with with T-lymphotropic retrovirus STLV-1]. / Morfoimmunologicheskie fenotipy T-kletochnykh nekhodzhinskikh zlokachestvennykh limfom pavianov i ikh sviaz' s T-limfotropnym retrovirusom STLV-1.
Arkh Patol
; 59(1): 19-25, 1997.
Article
en Ru
| MEDLINE
| ID: mdl-9139601
8 cytological types were detected among 58 cases of T-NHL of Papio hamadryas according to human updated Kiel classification (1988). 5 of them were of low grade (lymphocytic, prolymphocytic, T-zone, angioimmunoblastic, small cell pleomorphic) and 3-of high grade (medium and large cell pleomorphic, immunoblastic, large cell anaplastic CD30/Ki-1+). There are differences in a tumor structure and generalization in baboon and human lymphomas in spite of significant similarities. STLV-1 presence (antibodies in blood and virus genome fragments in the lymphoma cell DNA) detected by PCR-amplification in 7 investigated types of baboon T-NHL. CD4+ immune phenotypes were predominant in T-cell baboon lymphomas, while CD8+ phenotypes were rare. Abnormal phenotypes in some cases were also detected in the three-color FACS-analyses.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfoma de Células T
/
Virus Linfotrópico T Tipo 1 de los Simios
Límite:
Animals
/
Humans
Idioma:
Ru
Revista:
Arkh Patol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Rusia