Neural monitoring system for circulating somatostatin in the hepatoportal area.
Nutrition
; 13(3): 225-9, 1997 Mar.
Article
en En
| MEDLINE
| ID: mdl-9131684
If a peptide hormone secreted from the gastroenteropancreatic (GEP) system is monitored by the hepatic vagal nerve, the nerve can signal the central nervous system and thereby exert control on its target organs. In this review, we offer a line of evidence for the hypothesis. When a physiological dose of somatostatin (SS), one of the GEP hormones, was injected into the rat portal vein, the spike discharge rate in the hepatic afferent vagus increased significantly. This SS-induced activation of the vagus was completely abolished by a prior administration of our monoclonal antibody to SS receptor into the portal vein. We further disclosed a morphological basis for this neural reception to SS in the hepatoportal area: the neural bodies, located beneath the endothelium of the rat portal vein, preferentially bound the exogenous SS injected intraportally as revealed immunohistologically. The bodies contained a structure of the nerve fiber arborizations resembling those of the afferent apparatus of Krause, on which the presence of SS receptor was confirmed histochemically using the anti-SS receptor antibody. These results provide a new insight into the receptor-mediated neural reception to GEP hormones in the hepatoportal area, implying the potential role of the reception in the GEP physiology.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sistema Porta
/
Nervio Vago
/
Somatostatina
/
Receptores de Somatostatina
/
Hígado
Límite:
Animals
Idioma:
En
Revista:
Nutrition
Asunto de la revista:
CIENCIAS DA NUTRICAO
Año:
1997
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos