Suppression of L-histidine decarboxylase mRNA expression by methyleugenol.
Biochem Biophys Res Commun
; 232(1): 188-91, 1997 Mar 06.
Article
en En
| MEDLINE
| ID: mdl-9125128
We investigated the effect of methyleugenol on anaphylaxis. Methyleugenol completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. Methyleugenol also inhibited local anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Moreover, methyleugenol dose-dependently inhibited histamine release in mast cells activated by compound 48/80 or anti-DNP IgE. Northern-blot analysis demonstrated that significantly reduced level of the mRNA of L-histidine decarboxylase (HDC) was expressed in mast cells treated with methyleugenol, compared to that without methyleugenol. We conclude that methyleugenol directly affect histamine release and HDC gene over-expression in mast cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ARN Mensajero
/
Eugenol
/
Histidina Descarboxilasa
Límite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
1997
Tipo del documento:
Article
País de afiliación:
Corea del Sur
Pais de publicación:
Estados Unidos