Preferential sensitivity of acrocentric chromosomes to the aneugenic effect of colchicine.
Teratog Carcinog Mutagen
; 16(5): 243-52, 1996.
Article
en En
| MEDLINE
| ID: mdl-9122890
In order to evaluate the predisposition to the aneuploidy-inducing agent colchicine (Col) on lymphocytes from trisomic 21 patients compared with their parents and with a control group of subjects without trisomic children, we performed the micronucleus (MN) assay associated with C-banding, CREST staining, and nucleolar organizing region (NOR)-banding. According to our results Col behaves as an aneugenic agent independently of the population studied for CREST and C-banding. The Col-induced MN exhibited a clear majority (> 80%) of positive NOR-MN, meaning that they contain a NOR region transcriptionally active or inactive. The same data were observed in trisomic 21 individuals, their parents, and the control group, without significant differences between them. These results seem to suggest a preferential effect of the aneugen Col on acrocentric chromosomes in all of the three groups studied.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cromosomas Humanos Par 21
/
Colchicina
/
Supresores de la Gota
/
Aneuploidia
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Teratog Carcinog Mutagen
Año:
1996
Tipo del documento:
Article
País de afiliación:
Portugal
Pais de publicación:
Estados Unidos