Imipenem-resistant Ps. aeruginosa bacteraemia in cancer patients: risk factors, clinical features and outcome.

Krcméry, V; Trupl, J; Kunová, A; Spánik, S; Ilavská, I; Hel'pianska, L; Bezáková, I; Drgona, L; Oravcová, E; Studená, M; Lacka, J; Sevcíková, L; Koren, P; Kukucková, E; Stopková, K; Krupová, I; Grausová, S; Svec, J

Krcméry, V; Trupl, J; Kunová, A; Spánik, S; Ilavská, I; Hel'pianska, L; Bezáková, I; Drgona, L; Oravcová, E; Studená, M; Lacka, J; Sevcíková, L; Koren, P; Kukucková, E; Stopková, K; Krupová, I; Grausová, S; Svec, J.

Afiliación

Krcméry V; Department of Medicine, Tyrnaviensis University, Trnava, Bratislava.

Bratisl Lek Listy ; 97(11): 647-51, 1996 Nov.

Article en En | MEDLINE | ID: mdl-9117427

RESUMEN

Ninety nine patients with 101 bacteraemic episodes due to Ps. aeruginosa (PA) within 6 years were divided into two groups according to their resistance to imipenem-91 due to imipenem sensitive (ISPA) and 10 due to resistant (IRPA). Risk factors, the clinical course and the outcome were evaluated and compared. Acute leukaemia, prolonged neutropenia, previous therapy with amikacin, third generation of cephalosporins, imipenem and prophylaxis by quinolones were significantly more frequently associated with IRPA. Imipenem resistant PA bacteraemia were associated with higher incidence of septic shock (40% vs 19.8%, p < 0.02) and death (33.3%) than ISPA bacteraemias. Since 1992, when first IRPA appeared, the incidence of imipenem resistance increased tenfold, and in 1994, up to 10% of PA causing bloodstream infections in cancer patients in our center were imipenem resistant. (Tab. 3, Ref. 8.).

Asunto(s)

Bacteriemia/tratamiento farmacológico; Imipenem/uso terapéutico; Neoplasias/complicaciones; Infecciones por Pseudomonas/tratamiento farmacológico; Pseudomonas aeruginosa/efectos de los fármacos; Tienamicinas/uso terapéutico; Adulto; Bacteriemia/complicaciones; Bacteriemia/etiología; Farmacorresistencia Microbiana; Humanos; Infecciones por Pseudomonas/complicaciones; Infecciones por Pseudomonas/etiología; Estudios Retrospectivos; Factores de Riesgo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Infecciones por Pseudomonas / Tienamicinas / Imipenem / Bacteriemia / Neoplasias Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Bratisl Lek Listy Año: 1996 Tipo del documento: Article Pais de publicación: Eslovaquia

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