PcG complexes and chromatin silencing.
Curr Opin Genet Dev
; 7(2): 249-58, 1997 Apr.
Article
en En
| MEDLINE
| ID: mdl-9115424
Silencing complexes in yeast and in the fly have many similarities. This repressive complex is assembled by a chain of recruitment; its extent and stability depend on the concentration of components and affect an extended chromatin region, probably through interactions with nucleosomes. Recent results show that assembly of the complex is antagonized by transcriptional activity in the region but is favored by interactions with other complexes nearby or in other regions that associate in the same nuclear environment. How such a complex interferes with transcriptional activity is not entirely clear but current evidence suggests that they compete with the chromatin structure required for the binding of activators.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cromatina
/
Proteínas de Insectos
/
Proteínas de Drosophila
Límite:
Animals
Idioma:
En
Revista:
Curr Opin Genet Dev
Asunto de la revista:
GENETICA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Suiza
Pais de publicación:
Reino Unido