The erbB 2 oncogene and chemotherapy: a mini-review.

Torre, E A; Salimbeni, V; Fulco, R A

Torre, E A; Salimbeni, V; Fulco, R A.

Afiliación

Torre EA; Sezione Decentrata di Tecnologie Biomediche dell'Istituto Tumori di Genova, Messina, Italy.

J Chemother ; 9(1): 51-5, 1997 Feb.

Article en En | MEDLINE | ID: mdl-9106018

RESUMEN

The erbB 2 gene, also known as Her-2/neu, is an oncogene that encodes a transmembrane glycoprotein receptor. When overexpressed erbB 2 is an indicator of poor prognosis in a number of cancers. Recent studies show that erbB 2 expression plays a role in the prediction of responsiveness to adjuvant treatment: tumors that had an overexpression of the oncogene were less responsive to treatment than those with a normal amount. Some studies on this oncogene have examined the production of anti-erbB 2 monoclonal antibodies and evaluated the combined effect of monoclonal antibody and chemotherapeutics.

Asunto(s)

Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Genes erbB-2; Neoplasias/tratamiento farmacológico; Anticuerpos Monoclonales; Quimioterapia Adyuvante; Humanos; Inmunotoxinas/uso terapéutico; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/metabolismo; Neoplasias/metabolismo; Pronóstico

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Genes erbB-2 / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Chemother Asunto de la revista: ANTINEOPLASICOS / TERAPIA POR MEDICAMENTOS Año: 1997 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido

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