Conditioning of body temperature and natural killer cell activity with arecoline, a muscarinic cholinergic agonist.

Ghanta, V K; Demissie, S; Hiramoto, N S; Hiramoto, R N

Ghanta, V K; Demissie, S; Hiramoto, N S; Hiramoto, R N.

Afiliación

Ghanta VK; Department of Biology, University of Alabama at Birmingham, 35294, USA.

Neuroimmunomodulation ; 3(4): 233-8, 1996.

Article en En | MEDLINE | ID: mdl-9094445

RESUMEN

Arecoline, a muscarinic cholinergic agonist, was found to depress body temperature and elevate the activity of preactivated natural killer (NK) cells. To demonstrate that the unconditioned responses produced by arecoline were mediated through central nervous system pathways, we used the drug as an unconditioned stimulus. By pairing camphor odor (conditioned stimulus) with arecoline (unconditioned stimulus), it was possible to simultaneously condition both a decrease in body temperature and augmentation of NK cell activity. The observations suggest that although both the modulation of body temperature and NK cell activities are integrated at the level of the hypothalamus, these pathways of regulation can be differentiated.

Asunto(s)

Arecolina/farmacología; Temperatura Corporal/efectos de los fármacos; Condicionamiento Psicológico/efectos de los fármacos; Células Asesinas Naturales/efectos de los fármacos; Animales; Femenino; Ratones; Ratones Endogámicos BALB C

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arecolina / Temperatura Corporal / Células Asesinas Naturales / Condicionamiento Psicológico Límite: Animals Idioma: En Revista: Neuroimmunomodulation Asunto de la revista: ALERGIA E IMUNOLOGIA / NEUROLOGIA Año: 1996 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza

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