Elevation of interleukin 6 levels in patients with chronic hepatitis due to hepatitis C virus.

Malaguarnera, M; Di Fazio, I; Romeo, M A; Restuccia, S; Laurino, A; Trovato, B A

Malaguarnera, M; Di Fazio, I; Romeo, M A; Restuccia, S; Laurino, A; Trovato, B A.

Afiliación

Malaguarnera M; Department of Internal Medicine and Geriatrics, University of Catania, Italy.

J Gastroenterol ; 32(2): 211-5, 1997 Apr.

Article en En | MEDLINE | ID: mdl-9085170

RESUMEN

Interleukin 6 (IL-6) is a pleiotropic cytokine produced by a wide variety of lymphoid and non-lymphoid tissues. We studied the relationship between IL-6 and the liver in an attempt to elucidate this cytokine's role in hepatitis C-induced liver inflammation. We investigated the behavior of serum IL-6 in 25 patients with chronic hepatitis C (divided into three groups depending on severity) and in 27 healthy controls. Our results showed a significant elevation (P < 0.0001) in serum IL-6 levels in the patients with chronic hepatitis C, correlated with the histological activity index (HAI) and their HCV-RNA serum levels. This rise may represent the expression of the hepatitis C virus-induced inflammatory state.

Asunto(s)

Hepatitis C/sangre; Hepatitis Crónica/sangre; Interleucina-6/sangre; Estudios de Casos y Controles; Femenino; Hepatitis C/patología; Hepatitis Crónica/patología; Hepatitis Crónica/virología; Humanos; Hígado/patología; Masculino; Persona de Mediana Edad; ARN Viral/sangre

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-6 / Hepatitis C / Hepatitis Crónica Tipo de estudio: Observational_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 1997 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Japón

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