Structural studies and synthetic applications of Baeyer-Villiger monooxygenases.

Willetts, A

Willetts, A.

Afiliación

Willetts A; Department of Biological Sciences, University of Exeter, Devon, UK. A.J.Willetts@exeter.ac.uk

Trends Biotechnol ; 15(2): 55-62, 1997 Feb.

Article en En | MEDLINE | ID: mdl-9081299

RESUMEN

Baeyer-Villiger monooxygenases (BVMOs) are enzymes able to perform highly regio-plus steroselective nucleophilic and electrophilic biooxygenations on various substrates. The resultant chiral products (lactones and sulfoxides) can be valuable for the chemoenzymatic synthesis of a wide range of useful compounds. Recent studies have provided a number of alternative active-site models that attempt to explain the exquisite and unusual selectivity of BVMOs. This article reviews some of the established applications, and considers the merits of the various predictive models.

Asunto(s)

Flavoproteínas/química; Oxigenasas de Función Mixta/química; Oxigenasas de Función Mixta/metabolismo; Oxigenasas/química; Oxigenasas/metabolismo; Secuencia de Aminoácidos; Sitios de Unión; Flavoproteínas/metabolismo; Cinética; Sustancias Macromoleculares; Datos de Secuencia Molecular; NAD/metabolismo; NADP/metabolismo; Especificidad por Sustrato

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxigenasas / Flavoproteínas / Oxigenasas de Función Mixta Tipo de estudio: Prognostic_studies Idioma: En Revista: Trends Biotechnol Año: 1997 Tipo del documento: Article Pais de publicación: Reino Unido

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