Prospective longitudinal analysis of viral load and surrogate markers in relation to clinical progression in HIV type 1-infected persons.

Bruisten, S M; Frissen, P H; Van Swieten, P; Harrigan, P R; Kinghorn, I; Larder, B; Weigel, H M; De Vries, E; Regez, R M; Henrichs, J H; Koot, M; Huisman, J G

Bruisten, S M; Frissen, P H; Van Swieten, P; Harrigan, P R; Kinghorn, I; Larder, B; Weigel, H M; De Vries, E; Regez, R M; Henrichs, J H; Koot, M; Huisman, J G.

Afiliación

Bruisten SM; Department of Clinical Viro-Immunology, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.

AIDS Res Hum Retroviruses ; 13(4): 327-35, 1997 Mar 01.

Article en En | MEDLINE | ID: mdl-9071432

RESUMEN

The temporal relationship between viral and surrogate markers and clinical status was analyzed prospectively every 8 weeks in 34 asymptomatic HIV-1-infected persons. After 3 years, 25 persons remained clinically healthy whereas 9 persons showed clinical progression. In accordance with other reports we found that at study entry HIV-RNA load was predictive of clinical progression. All markers tested evolved significantly in time in both progressors and nonprogressors. The HIV RNA load in plasma and HIV DNA load in T cells were linearly related only in nonprogressors. In addition, the RNA/DNA ratio during follow-up was significantly higher in progressors, indicating a higher replication rate in progressors. The HIV DNA load correlated inversely with CD4+ T cell counts and positively with p24 antigenemia in both nonprogressors and progressors. A significant correlation of HIV DNA load with SI phenotype occurred in progressors only. HIV RNA levels correlated with beta 2-microglobulin level and with p24 antigenemia but not with SI phenotype. These three markers can all routinely be measured in plasma; however, only the HIV RNA levels appear to be informative for clinical progression. Six to 8 months before clinical progression, an SI phenotype switch, increased HIV RNA in plasma, and decreased CD4+ T cell counts were all indicative of an impending clinical event.

Asunto(s)

Linfocitos T CD4-Positivos/citología; Proteína p24 del Núcleo del VIH/sangre; Infecciones por VIH/virología; VIH-1; Microglobulina beta-2/análisis; Adulto; Recuento de Linfocito CD4; Progresión de la Enfermedad; Estudios de Seguimiento; Infecciones por VIH/sangre; Infecciones por VIH/inmunología; VIH-1/genética; VIH-1/inmunología; Humanos; Estudios Longitudinales; Análisis por Apareamiento; Persona de Mediana Edad; Valor Predictivo de las Pruebas; Estudios Prospectivos; ARN Viral; Factores de Tiempo

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Infecciones por VIH / Microglobulina beta-2 / VIH-1 / Proteína p24 del Núcleo del VIH Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Middle aged Idioma: En Revista: AIDS Res Hum Retroviruses Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 1997 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links