Interleukin-6 in hepatitis C cirrhosis.

Malaguarnera, M; Trovato, B A; Laurino, A; Di Fazio, I; Romeo, M A; Motta, M

Malaguarnera, M; Trovato, B A; Laurino, A; Di Fazio, I; Romeo, M A; Motta, M.

Afiliación

Malaguarnera M; Department of Internal Medicine and Geriatrics University of Catania, Italy.

Panminerva Med ; 38(4): 207-10, 1996 Dec.

Article en En | MEDLINE | ID: mdl-9063027

RESUMEN

Interleukin-6 (IL-6) is a pleiotropic cytokine involved in numerous diseases but the correlation between liver fibrosis and IL-6 role is not clear. We studied IL-6 levels in 50 HCVAb+ patients with liver cirrhosis (grouped into A, B and C, Child classes) and in 27 healthy control subjects. IL-6 serum levels were significantly increased in the former (p < 0.005) suggesting that IL-6 stimulates and sustains liver fibrosis. In cirrhotic subjects, the rise in IL-6 serum levels is due to impaired hepatic clearance of this cytokine, while its production remains steady.

Asunto(s)

Hepacivirus; Hepatitis C/sangre; Interleucina-6/sangre; Cirrosis Hepática/sangre; Adulto; Anciano; Femenino; Humanos; Cirrosis Hepática/virología; Masculino; Persona de Mediana Edad

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-6 / Hepatitis C / Hepacivirus / Cirrosis Hepática Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Panminerva Med Año: 1996 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia

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