Frequent loss of chromosome 14 in atypical and malignant meningioma: identification of a putative 'tumor progression' locus.

Menon, A G; Rutter, J L; von Sattel, J P; Synder, H; Murdoch, C; Blumenfeld, A; Martuza, R L; von Deimling, A; Gusella, J F; Houseal, T W

Menon, A G; Rutter, J L; von Sattel, J P; Synder, H; Murdoch, C; Blumenfeld, A; Martuza, R L; von Deimling, A; Gusella, J F; Houseal, T W.

Afiliación

Menon AG; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati Medical Center, Ohio 45267-0524, USA.

Oncogene ; 14(5): 611-6, 1997 Feb 06.

Article en En | MEDLINE | ID: mdl-9053860

RESUMEN

Formation of meningiomas has been associated with the loss of genetic material on chromosome 22. To approach the additional chromosomal events that underlie progression of these tumors to malignancy, we have examined several other chromosomal regions for loss of heterozygosity (LOH) in these tumors. Fifty-eight tumors, comprising 43 benign meningiomas, 11 atypical meningiomas and four malignant meningiomas, were examined. While the loss of chromosome 22 was seen in approximately half of all these tumors, regardless of their malignancy, the most frequent chromosomal losses observed in the malignant and atypical tumors were on the long arm of chromosome 14. Thirty-nine tumors were informative for at least one of the three markers on chromosome 14 that we tested. Of these, 7/14 malignant and atypical tumors showed LOH in contrast to only 1/25 benign tumors. Other loci that showed LOH in malignant tumors, although at a much lower frequency, were on chromosomes 17p and 1p. The high frequency of LOH for loci on chromosome 14q in atypical and malignant tumors suggests the presence of a tumor progression gene at this locus. In one of the malignant meningiomas heterozygosity was lost at D14S13 and D14S16 but retained at the proximal marker D14S43 as well as the more distal marker D14S23. This suggests that an interstitial deletion occurred in this tumor which should be useful for further refining the position of the putative tumor progression locus.

Asunto(s)

Deleción Cromosómica; Cromosomas Humanos Par 14; Neoplasias Meníngeas/genética; Meningioma/genética; Mapeo Cromosómico; Cromosomas Humanos Par 22; Marcadores Genéticos; Humanos; Neoplasias Meníngeas/patología; Neoplasias Meníngeas/cirugía; Meningioma/patología; Meningioma/cirugía; Reacción en Cadena de la Polimerasa; Polimorfismo Genético

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 14 / Deleción Cromosómica / Neoplasias Meníngeas / Meningioma Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 1997 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links