High-pressure liquid chromatographic analysis of methotrexate in presence of its degradation products.
J Pharm Sci
; 66(9): 1219-22, 1977 Sep.
Article
en En
| MEDLINE
| ID: mdl-903856
Two high-pressure liquid chromatographic methods are described for the quantitative determination of methotrexate in the presence of its contaminants and degradation products. Method 1 takes less than 15 min and is recommended for routine assays of methotrexate in commercial products. Method 2 takes about 35 min and is the method of choice to detect and quantitate large amounts of degradation products. Quantitation to a level of 1 microgram of methotrexate/ml is feasible by these methods and thus provides potential applicability for the analysis of methotrexate in biological fluids.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Metotrexato
Idioma:
En
Revista:
J Pharm Sci
Año:
1977
Tipo del documento:
Article
Pais de publicación:
Estados Unidos