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Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats.
Smolders, I; Van Belle, K; Ebinger, G; Michotte, Y.
Afiliación
  • Smolders I; Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universteit Brussel, Belgium.
Eur J Pharmacol ; 319(1): 21-9, 1997 Jan 14.
Article en En | MEDLINE | ID: mdl-9030893
Limbic seizures were provoked in freely moving rats by intrahippocampal administration of the muscarinic receptor agonist pilocarpine via a microdialysis probe (10 mM for 40 min at 2 microliters/min). Changes in extracellular hippocampal and cerebellar glutamate, aspartate and gamma-aminobutyric acid (GABA) levels were monitored during and after pilocarpine administration. Effects of systemic or local administration of anticonvulsants on the seizures and concomitant changes in amino-acid concentrations, were investigated. Pilocarpine-induced seizures were completely abolished after intraperitoneal premedication for 7 days with phenobarbital (15 mg/kg per day) and after intrahippocampal administration of 10 mM phenobarbital and 1 mM carbamazepine (180 min at 2 microliters/min). Rats premedicated with carbamazepine (5 mg/kg per day) still developed seizures. The changes in extracellular hippocampal amino-acid levels suggest that glutamate, aspartate and GABA are not involved in seizure onset, but may play a role in seizure maintenance and/or spread in the pilocarpine animal model of epilepsy. The increases in extracellular amino acids in ipsi- and contralateral cerebellum following limbic seizures provoked in the hippocampus, probably play a role in the 'reversed' diaschisis phenomenon.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pilocarpina / Convulsiones / Cerebelo / Aminoácidos / Hipocampo Límite: Animals Idioma: En Revista: Eur J Pharmacol Año: 1997 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Países Bajos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pilocarpina / Convulsiones / Cerebelo / Aminoácidos / Hipocampo Límite: Animals Idioma: En Revista: Eur J Pharmacol Año: 1997 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Países Bajos