Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks.
Curr Opin Genet Dev
; 7(1): 99-104, 1997 Feb.
Article
en En
| MEDLINE
| ID: mdl-9024627
A convergence of information from biochemistry, yeast and mammalian genetics, immunology, and radiation biology has permitted identification of some of the protein participants - Ku, DNA-PK, XRCC4 - and the reaction intermediates in DNA end joining, suggesting how broken chromosomal ends may be recognized and repaired in eukaryotic cells. Some components may be defective in inherited disorders.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Nucleares
/
Proteínas Serina-Treonina Quinasas
/
ADN Helicasas
/
Proteínas de Saccharomyces cerevisiae
/
Antígenos Nucleares
/
Proteínas de Unión al ADN
/
Reparación del ADN
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Curr Opin Genet Dev
Asunto de la revista:
GENETICA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido