Loss of expression of the p16 gene is frequent in malignant skin tumors.

Chang, T G; Wang, J; Chen, L W; Hsu, C Y; Chang, H W; Chen, J S; Cho, C L

Chang, T G; Wang, J; Chen, L W; Hsu, C Y; Chang, H W; Chen, J S; Cho, C L.

Afiliación

Chang TG; Institute of Life Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.

Biochem Biophys Res Commun ; 230(1): 85-8, 1997 Jan 03.

Article en En | MEDLINE | ID: mdl-9020067

RESUMEN

Expression of the p16 gene from 30 malignant skin tumors has been surveyed by immunohistochemical assay. Gene point mutations were detected by DNA direct sequencing and the mRNA level of gene expression was measured by RT-PCR. A silent point mutation of the p16 gene was found in only one patient. However, loss of expression of the p16 gene was noticed in 23 of 29 samples (79.3%). Correlation between loss of expression of the p16 gene and metastasis is significant (p = 0.0036). These findings suggest that loss of expression of the p16 gene may play a critical role in tumor progression of malignant skin tumors.

Asunto(s)

Proteínas Portadoras/biosíntesis; Genes Supresores de Tumor; Neoplasias Cutáneas/genética; Adenocarcinoma/genética; Carcinoma Basocelular/genética; Carcinoma de Células Escamosas/genética; Proteínas Portadoras/análisis; Inhibidor p16 de la Quinasa Dependiente de Ciclina; Hemangiosarcoma/genética; Humanos; Inmunohistoquímica; Melanoma/genética; Neurilemoma/genética; Reacción en Cadena de la Polimerasa; ARN Mensajero/análisis; ARN Mensajero/biosíntesis; Neoplasias Cutáneas/metabolismo; Neoplasias Cutáneas/patología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Proteínas Portadoras / Genes Supresores de Tumor Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 1997 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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