Characterization of csgA, a new member of the forespore-expressed sigmaG-regulon from Bacillus subtilis.

Shcheptov, M; Chyu, G; Bagyan, I; Cutting, S

Shcheptov, M; Chyu, G; Bagyan, I; Cutting, S.

Afiliación

Shcheptov M; Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104-6076, USA.

Gene ; 184(1): 133-40, 1997 Jan 03.

Article en En | MEDLINE | ID: mdl-9016963

RESUMEN

A new locus, csgA, has been identified in a search for developmental genes transcribed by E sigmaG in Bacillus subtilis. csgA has the potential to encode three small proteins, CsgAA, CsgAB and CsgAC. The latter two would be encoded by overlapping ORFs. csgA is expressed in the spore chamber of the differentiating cell and is under the control of sigmaG and the transcriptional regulatory protein SpoVT. Mutation of csgA did not affect spore formation but produced a subtle defect in the ability of the germinating spore to resume vegetative growth.

Asunto(s)

Bacillus subtilis/química; Proteínas Bacterianas/química; Regulón/genética; Secuencia de Aminoácidos; Proteínas Bacterianas/genética; Secuencia de Bases; Northern Blotting; Mapeo Cromosómico; Clonación Molecular; Regulación Bacteriana de la Expresión Génica/genética; Operón Lac/genética; Datos de Secuencia Molecular; Mutagénesis Sitio-Dirigida/genética; Mutación/genética; Análisis de Secuencia; Factor sigma/metabolismo; Factor sigma/farmacología; Esporas/metabolismo; Factores de Transcripción/metabolismo; beta-Galactosidasa/metabolismo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacillus subtilis / Proteínas Bacterianas / Regulón Tipo de estudio: Prognostic_studies Idioma: En Revista: Gene Año: 1997 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

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