Chitosan microspheres of diclofenac sodium: I. application of factorial design and evaluation of release kinetics.
J Microencapsul
; 13(2): 141-59, 1996.
Article
en En
| MEDLINE
| ID: mdl-8999120
In this study microspheres of diclofenac sodium, an anti-inflammatory agent, were prepared by utilizing a natural polysaccharide, chitosan-H. The objective of this investigation was to sustain the action of diclofenac sodium and to show the effect of various conditions on release kinetics. For this reason factorial design experiments were performed. The independent variables in the 3(3) factorial design were chitosan-H concentration, tripolyphosphate concentration and stabilization time, and in the 3(2) factorial design were chitosan-H and tripolyphosphate concentrations. The dependent variables, t50% and the total drug content were investigated by the polynomial equations. The release profiles were evaluated kinetically and the best fit was obtained by the Higuchi equation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quitina
/
Diclofenaco
Idioma:
En
Revista:
J Microencapsul
Asunto de la revista:
FARMACIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Reino Unido