Generalized prepubertal periodontitis. A report of 4 cases with the immunological findings.
J Clin Periodontol
; 23(12): 1104-11, 1996 Dec.
Article
en En
| MEDLINE
| ID: mdl-8997655
The clinical and immunological data from 4 patients with generalized prepubertal periodontitis are presented. The peripheral blood neutrophil chemotaxis was measured using zymosan activated sera as the chemoattractant. All of the 4 patients have shown depressed neutrophil chemotaxis compared to those of the healthy controls. Peripheral blood lymphocyte subpopulations were analysed by double-coloured flow cytometry using monoclonal antibodies for the receptors CD2, CD3, CD4, CD8, CD19, CD29, CD45RA+, 34,29dK, CD56. CD11b/CD18. Lymphocytes bearing CD3 receptors showed a significant decrease compared to those of the controls. Natural killer cells were lowered in 3 of the 4 cases. All of the patients showed a higher increase in CD11b/CD18 expression. The evaluation of CD11b/CD18 receptor in peripheral blood leukocytes may be of help explaining the rôle of neutrophils in the pathogenesis of the disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Periodontitis Agresiva
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Periodontol
Año:
1996
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Estados Unidos