Iodide, cytokines and TSH-receptor expression in Graves' disease.
Exp Clin Endocrinol Diabetes
; 104 Suppl 4: 68-74, 1996.
Article
en En
| MEDLINE
| ID: mdl-8981006
The present study was initiated to characterize thyrotropin receptor (TSH-R) expression in thyroids from patients with Graves' disease, as well as parameters that influence TSH-R expression either causally, such as interferon-gamma (IFN-gamma), the leading candidate among the cytokines thought to play a key role in the initiation of autoimmune thyroid disease, or therapeutically, such as iodide, which is used to prepare patients for surgery. Our data show that there is an average 4-fold increase of TSH-R mRNA levels in the thyroids of Graves' patients coming to surgery, which is paralleled by an increase in TSH-R protein levels and TSH binding capacity. The increase does not appear to be related to IFN-gamma since IFN-gamma transcripts are barely detectable in most Graves' patients. Iodide treatment causes a 2-fold decrease in TSH-R expression in association with significant decreases in major histocompatibility complex (MHC) class I and class II gene expression. These last data are compatible with a recently enunciated "transcription factor hypothesis" according to which abnormally high TSH-R and MHC class I and class II gene expression in Graves' thyroids are the result of a loss of the normal negative regulation of these genes necessary to allow the normal growth and function of the gland, yet preserve self-tolerance.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Tirotropina
/
Expresión Génica
/
Enfermedad de Graves
/
Interferón gamma
/
Yoduros
Límite:
Humans
Idioma:
En
Revista:
Exp Clin Endocrinol Diabetes
Asunto de la revista:
ENDOCRINOLOGIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Alemania