Aerosolization of imipenem/cilastatin prevents pseudomonas-induced acute lung injury.
J Antimicrob Chemother
; 38(5): 809-18, 1996 Nov.
Article
en En
| MEDLINE
| ID: mdl-8961050
Aerosolization of imipenem/cilastatin was compared with continuous intravenous infusions of the antibiotic for pharmacokinetic/pharmacodynamic analysis. The concentrations of imipenim/cilastatin in bronchoalveolar lavage fluids (BAL) obtained from rats exposed to the aerosolized antibiotic were significantly greater than the concentrations in BAL in the rats that had received intravenous infusions of imipenem/cilastatin. The two methods of antibiotic delivery were compared for their effects on bacterial-induced lung injury in rats that had Pseudomonas aeruginosa instilled into their airspaces. The aerosolization of antibiotic was associated with significantly decreased bacterial-induced lung injury. The high concentrations of antibiotic in the airspaces secondary to aerosolization appears to kill bacteria more quickly and preserve lung epithelial and endothelial integrity better than systemic delivery of the same antibiotic.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pseudomonas aeruginosa
/
Infecciones por Pseudomonas
/
Quimioterapia Combinada
/
Pulmón
Límite:
Animals
Idioma:
En
Revista:
J Antimicrob Chemother
Año:
1996
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Reino Unido