Concanavalin-A-induced open neural tube defects in chick embryos.

Inagaki, T; Wang, K C; Higbee, R G; Mclone, D G; Knepper, P A

Inagaki, T; Wang, K C; Higbee, R G; Mclone, D G; Knepper, P A.

Afiliación

Inagaki T; Division of Pediatric Neurosurgery, Children's Memorial Hospital, Northwestern University, Chicago, Illinois, USA.

Neurol Med Chir (Tokyo) ; 36(10): 691-6; discussion 696-7, 1996 Oct.

Article en En | MEDLINE | ID: mdl-8937089

RESUMEN

Open neural tube defects developed in 12 of 122 alive chick embryos treated with exogenous lectin (concanavalin-A) at stages between 10 or 14 as defined by Hamburger and Hamilton. Embryos treated at stage 10, the time of anterior neuropore closure, developed exencephaly or extensive neural openings from the level of rhombencephalon to the thoracic spinal cord, while embryos treated at stages between 11 and 14, at posterior neuropore closure, developed only small myeloschisis in the thoracolumbar region. The failure of neural tube closure at a critical time is a major cause of neural tube defects.

Asunto(s)

Concanavalina A/toxicidad; Defectos del Tubo Neural/inducido químicamente; Animales; Adhesión Celular/efectos de los fármacos; Embrión de Pollo; Ectodermo/efectos de los fármacos; Morfogénesis/efectos de los fármacos; Defectos del Tubo Neural/patología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Concanavalina A / Defectos del Tubo Neural Límite: Animals Idioma: En Revista: Neurol Med Chir (Tokyo) Año: 1996 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Japón

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