In vitro and in vivo characterization of a 99mTc complex with tris(hydroxymethyl)phosphine (THP).

Berning, D E; Katti, K V; Singh, P R; Higgenbotham, C; Reddy, V S; Volkert, W A

Berning, D E; Katti, K V; Singh, P R; Higgenbotham, C; Reddy, V S; Volkert, W A.

Afiliación

Berning DE; Department of Chemistry, University of Missouri, Columbia, USA.

Nucl Med Biol ; 23(5): 617-22, 1996 Jul.

Article en En | MEDLINE | ID: mdl-8905826

RESUMEN

The water-soluble, monophosphine ligand tris(hydroxymethyl)phosphine (THMP) was complexed with 99mTc. The 99mTc-THMP was formed in high radiochemical purity by simply mixing 99mTcO4- with THMP over a wide pH range. In vitro and in vivo studies indicated the complex to be highly stable under the respective conditions. HPLC analysis indicated a singular species with a retention time identical to the known [ReO2(THMP)4]1 complex. Results show that the hydroxymethylphosphine functionality is attractive for use in designing new 99mTc radiopharmaceuticals.

Asunto(s)

Compuestos de Organotecnecio/química; Compuestos de Organotecnecio/farmacocinética; Fosfinas/química; Fosfinas/farmacocinética; Tecnecio; Animales; Sangre; Cromatografía Líquida de Alta Presión; Humanos; Marcaje Isotópico/métodos; Compuestos de Organotecnecio/síntesis química; Fosfinas/síntesis química; Ratas; Ratas Sprague-Dawley; Distribución Tisular

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfinas / Compuestos de Organotecnecio / Tecnecio Límite: Animals / Humans Idioma: En Revista: Nucl Med Biol Asunto de la revista: BIOLOGIA / MEDICINA NUCLEAR Año: 1996 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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