GABA metabolism controls inhibition efficacy in the mammalian CNS.

Golan, H; Talpalar, A E; Schleifstein-Attias, D; Grossman, Y

Golan, H; Talpalar, A E; Schleifstein-Attias, D; Grossman, Y.

Afiliación

Golan H; Department of Physiology, Faculty of Health Sciences, Ben-Gurion University, Negev, Beer-Sheva, Israel.

Neurosci Lett ; 217(1): 25-8, 1996 Oct 11.

Article en En | MEDLINE | ID: mdl-8905731

RESUMEN

The effects of changes in gamma-aminobutyric acid (GABA) metabolism or inhibitory processes was studied in the perforant path-dentate gyrus synapses in rat cortico-hippocampal slices, and in the monosynaptic-reflex circuit in isolated newborn, rat spinal cord. GABA metabolism was modulated by pharmacological block of either the anabolic enzyme glutamate decarboxylase (GAD) or the catabolic enzyme GABA transaminase (GABA-T). The results support the notion that GABA concentration determines the efficacy of inhibition in these regions of the central nervous system (CNS).

Asunto(s)

Sistema Nervioso Central/fisiología; Inhibición Neural/fisiología; Ácido gamma-Aminobutírico/metabolismo; Ácido 3-Mercaptopropiónico/farmacología; 4-Aminobutirato Transaminasa/antagonistas & inhibidores; Animales; Corteza Cerebral/fisiología; Inhibidores Enzimáticos/farmacología; Potenciales Evocados/fisiología; Glutamato Descarboxilasa/antagonistas & inhibidores; Hipocampo/fisiología; Técnicas In Vitro; Ratas; Ratas Sprague-Dawley; Médula Espinal/fisiología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Central / Ácido gamma-Aminobutírico / Inhibición Neural Límite: Animals Idioma: En Revista: Neurosci Lett Año: 1996 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Irlanda

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