Development of a laboratory animal model of postoperative small intestinal adhesion formation in the rabbit.
Can J Vet Res
; 60(4): 296-304, 1996 Oct.
Article
en En
| MEDLINE
| ID: mdl-8904666
In order to establish a model of postoperative intestinal adhesions that would simulate the problem experienced in horses, New Zealand White rabbits were utilized to compare two models of adhesion formation that had been successful in the horse, an ischemic strangulating obstruction (ISO) model and a serosal scarification model. An untreated control group was compared with animals subjected to 1, 2, 3 and 4 h periods of ISO, and to serosal scarification. At postmortem examination 14 d postoperatively, the number of rabbits in each group with adhesions was recorded. Serosal scarification was significantly more consistent at producing adhesions than ISO (Fisher's exact test, P = 0.0022). The 3 h of ISO group was significantly different from the control group: however, compared to the serosal scarification group, fewer animals had adhesions and one animal died of complications associated with the experimental procedure. Based on these results, serosal scarification was selected as the best model for utilization in further studies of adhesion prevention.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Complicaciones Posoperatorias
/
Conejos
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Adherencias Tisulares
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Modelos Animales de Enfermedad
Tipo de estudio:
Etiology_studies
/
Incidence_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Can J Vet Res
Asunto de la revista:
MEDICINA VETERINARIA
Año:
1996
Tipo del documento:
Article
Pais de publicación:
Canadá